On 4 and 5 May, the Permanent Representative of Lithuania Ambassador Andrius Krivas took the floor at the 38th session of the Working Group of Universal Periodic Review (UPR) to address the human rights situation in Estonia and Belgium.

On 30 April, the Vice-Minister of Foreign Affairs of Lithuania Egidijus Meilūnas met with the newly appointed Ambassador of Indonesia to Lithuania Dewi Savitri Wahab to discuss the bilateral relationship and possibilities to strengthen it.

On 29 April, the Vice-Minister of Foreign Affairs of Lithuania Mantas Adomėnas took part in an informal video conference of Foreign Affairs Ministers (Development). The meeting focused on the Future European Financial Architecture for Development, actions and measures to be taken for the improvement of the institutional framework.

On 20 April, at a meeting of the United Nations Economic and Social Council in New York, Lithuania was elected as a member of the UN Commission on Narcotic Drugs (CND) for the quadrennial period 2022–2025. In a group of Eastern European countries, four countries – Lithuania, Slovenia, Croatia and Russia – were candidates for the 3 vacant seats. Slovenia and Russia were also elected to the CND.

On 20 April, at the 65th session of the Executive Council of the Organisation for the Prohibition of Chemical Weapons (OPCW), the Permanent Representative of Lithuania to the OPCW, Ambassador Vidmantas Purlys was elected Vice-Chair of the Executive Council of the OPCW to serve in that office for a period of one year.

On 15 April, the the Vice-Minister of Foreign Affairs of Lithuania Mantas Adomėnas visited Bucharest, where he took part in bilateral consultations with the State Secretary of the Romanian Ministry of Foreign Affairs Dănuţ Neculăesc and the State Secretary for Global Affairs and Diplomatic Strategies Cornel Feruţă.

On 15 April,  the Lithuanian and Turkish Ministries of Foreign Affairs held online political consultations to discuss bilateral and international issues, cooperation within NATO and the European Union. The Lithuanian delegation was led by the Foreign Vice-Minister Arnoldas Pranckevičius, while the Turkish delegation was headed by the Deputy Minister of Foreign Affairs of Turkey Faruk Kaymakcı.

On 14 April, the Ambassador of Lithuania Dainius Junevičius presented his letters of credence to the President of South Africa Cyril Ramaphosa.

On 13 April, the Vice-Minister of Foreign Affairs of Lithuania Egidijus Meilūnas met with the Ambassador of Ukraine to Lithuania Volodymyr Yatsenkivskyi and discussed the situation in eastern Ukraine, the region's security situation, as well as bilateral and multilateral cooperation.